Since each adult Orinoco Pleco tends to occupy its own small territory on the aquarium bottom, a tank of at least 200 liters (53 US gallons) will be required for comfortable keeping of a group of 2–3 fish. In this case, the aquarium's bottom area is more important than its height. The aquascape should include many hiding places. Grottoes and caves formed by intertwined driftwood or rock piles will look most natural. As an alternative, decorative ceramic elements can be used. Some aquarists even use PVC pipe fragments. Shade-loving aquatic plants, as well as floating plants that provide additional shading, will be a good addition. It is recommended to maintain water parameters in the range of slightly acidic pH values and low hardness (GH). Aquarium care is standard and includes several essential procedures: weekly partial water changes, removal of organic waste, and regular equipment checks. Unlike many related species, the Orinoco Pleco prefers a more varied diet, so its diet should not be limited exclusively to plant-based food. The basis of the diet can be common flakes, granules, and tablets containing protein components.