For a group of 2–3 such catfishes, an aquarium of at least 250 liters will be optimal. In terms of decor, special attention should be paid to the lower stratum, as the Orinoco Raphael Catfish spends a significant part of its life there. It is recommended to create both open areas and appropriately sized shelters, for example, from large snags. The catfish is safe for aquarium plants. Nevertheless, it is preferable to use hardy species with well-developed root systems, or those that can grow on the surfaces of snags or stones. In terms of care, it is relatively undemanding and adapts well to various conditions. Aquarium maintenance includes standard procedures: weekly partial water changes with fresh water, removal of organic waste, and regular equipment checks.