For keeping one or two Squeaking Orinoco Catfish, an aquarium of at least 500 liters is required. Hiding places are extremely important in the decor: these can be snags, rock formations, or other decorative material, both natural and artificial. A soft sandy substrate is preferred. Since the fish is nocturnal, the intensity of lighting is not critical; during daylight hours, it will remain in shelters. Keeping conditions largely depend on the fish's origin—from Asia or Siberia. The further south the habitat, the higher the required water temperature: for Amur catfish, a range of 16–25°C is considered comfortable, while for Asian catfish it is 23–27°C. In any case, these fish need clean water and tolerate the accumulation of organic waste poorly.