Agassiz's Corydoras, like other members of the genus, is highly sensitive to water quality and substrate condition. The main cause of diseases is non-compliance with environmental parameters, which leads to damage or erosion of the barbels, through which secondary infections can enter the body. For prevention, it is necessary to use a soft, fine-grained substrate without sharp edges and maintain cleanliness in the bottom layer. Fish are susceptible to typical aquarium fish diseases when keeping conditions are violated, including skin and gill lesions from parasites or fungal infections. High-quality filtration and regular water changes are the main methods of disease prevention. If signs of illness appear, such as apathy, discoloration, or fin damage, the ammonia and nitrite levels should be checked, and the chemical composition of the water should be stabilized.