Keeping Gladys's Corydoras requires approaches that differ significantly from keeping tropical relatives. It needs cool water, with a temperature not exceeding 16°C, high dissolved oxygen content, and significant carbonate hardness. In aquarium design, rocky elements are preferred: fine gravel, boulders, and rock fragments. Creating an internal current will be beneficial. Regular aquarium maintenance includes standard procedures. High water quality is ensured by weekly 30–40% water changes with fresh water and timely removal of organic deposits. Equipment requires periodic preventive maintenance, depending on its configuration. In terms of diet, Gladys's Corydoras will readily accept most aquarium fish foods of appropriate size, including dry, freeze-dried, gel, live, and frozen products. Regarding behavior and compatibility, it is a peaceful and sociable fish that prefers to stay in a group of its own kind. Due to specific habitat requirements, the choice of compatible species is limited. Preference should be given to fish capable of tolerating low temperatures and moderate currents. Possible tank mates include classic goldfish or some species of loaches.