For a group of 5–6 fish, an aquarium with a volume of 40–50 liters will be optimal. Keeping these inhabitants is not difficult. Hypsolebias picturatus requires soft, acidic water, the temperature of which should not exceed 28–30°C. A substrate of fallen leaves from various trees, as well as natural snags, is preferable. These natural elements will release tannins, giving the water a characteristic brownish tint, typical of swampy water bodies. When choosing plants, preference should be given to floating species, which will provide additional shading for the aquarium. Live foods such as brine shrimp, large daphnia, bloodworms, and similar are crucial for their diet. Due to their short lifespan, Hypsolebias picturatus do not have time to adapt to dry alternative foods.