Thanks to their modest size, this species can be successfully kept in aquariums of various volumes. Although Poecilia picta does not have specific requirements for decor, it is recommended to use many aquatic plants, including floating species, to create comfortable conditions. High water hardness can be maintained by adding shells, limestone fragments, and other carbonate materials. The fish prefers brackish water; in nature, salinity levels are unstable and can fluctuate from 5 to 20 or more grams of salt per liter, and replicating such periodic changes in the aquarium will be beneficial. Poecilia picta can survive in freshwater, but reproduction may be difficult under such conditions. For long-term keeping, it is crucial to ensure water purity with minimal contaminants—for example, nitrate concentration should not exceed 50 mg/L. An important and mandatory procedure is weekly partial water changes (10–15% of the total volume) with fresh water, as well as regular removal of organic debris.