Breeding Simpsonichthys presents certain difficulties due to their specific reproductive characteristics. In their natural environment, spawning occurs at the end of the wet season, heralding the onset of drought. The fish lay their eggs in a layer of substrate. As the body of water dries up, the fertilized eggs remain in the semi-dry substrate, where they stay for several months. With the first rains, the fry appear. In a home aquarium, it is necessary to recreate these seasonal changes. Specially prepared fibrous peat, coconut fibers, or their artificial analogues are used as a spawning substrate. The chosen material should be easy to remove from the aquarium and retain moisture well. As soon as eggs are visible on the surface of the substrate, it is carefully removed, gently squeezed, and dried for 2–3 hours on paper towels at room temperature. Then the substrate is placed in a plastic bag, which is tightly tied with a rubber band, or in a closed plastic container. It is stored in a dark place at a temperature of 26°C. The incubation period lasts 11 weeks. After this, the substrate is removed, placed in a container, and filled with soft water at a temperature of 23–24°C. The first fry usually appear in about an hour.