Tetragonopterus prefers a soft, slightly acidic aquatic environment for its existence. It is noteworthy that in natural conditions, the fish can even be found in brackish water, for example, in the estuaries of the Paraná and Uruguay rivers (Rio de la Plata), where fresh waters mix with salty waters from the Atlantic Ocean. This species is very sensitive to water quality, poorly tolerating nitrate concentrations above 50 mg/L. For successful and long-term keeping in an aquarium, the uninterrupted functioning of the filtration system is key. Weekly partial water changes with fresh water, accompanied by the removal of all organic waste such as food residues and excrement, are also important. The optimal aquarium volume for a shoal of 8–10 fish starts from 350–400 liters. In aquarium design, it is important to harmoniously combine open swimming areas with free spaces where fish can hide in dense plant thickets and among snags. Lighting should be kept subdued. Experienced aquarists often add leaves from certain trees to the aquarium; their decomposition releases tannins, giving the water a characteristic brownish tint, which mimics the conditions of their natural habitat. In the wild, their diet consists mainly of small invertebrates. In aquarium conditions, dry foods enriched with proteins can be offered. Nevertheless, for full development, supplements in the form of live or frozen brine shrimp, bloodworms, daphnia, and similar products will be beneficial.