Zebra Hypancistrus often spawn in home aquariums, so with suitable conditions, the appearance of fry is only a matter of time. To control the onset of the breeding period and ensure the safety of the offspring, a breeding tank can be used. This is usually a small tank with a volume of 30 liters or more. In its setup, shelters are crucial, which can be formed from small ceramic pots laid on their side, sections of PVC pipes, or special decorative elements imitating underwater grottoes and caves. The entrance hole should be only slightly wider than the fish. The shelter is placed near air diffusers to ensure a high level of oxygen and water circulation. Plants and substrate are not required in the breeding tank. Water parameters such as pH, dGH, and temperature should match the main aquarium. A stimulus for spawning is a water change (50–70% of the volume) with fresh water that is 2–4°C cooler, which mimics the rainy season in the wild. This procedure is repeated every 2–3 days. After some time, the catfish will enter the breeding period. Males, having chosen a suitable shelter, will begin to invite females there. Once the pair unites, they seclude themselves for several days. Then the female swims away, and the male remains to protect and care for the clutch. Usually, 7 to 15 eggs are laid. The fry hatch after a week, and after another 2–3 days, they emerge from the shelter and begin to swim freely. After this point, the male can be returned to the main aquarium. The fry should be fed specialized fry food for aquarium fish, as well as Artemia nauplii, microworms, and similar products. Fry are very voracious, so access to food should be constant.