Most Apistogramma macmasteri offered for sale are bred on commercial fish farms; wild specimens are extremely rare. This means their adaptation to aquarium conditions is quite straightforward. These fish will be comfortable in an aquarium of at least 40 litres, equipped with a sandy substrate, live or artificial plants, and several shelters such as driftwood or other decorative elements. Lighting should be kept dimmed, which can be achieved by using floating plants on the water surface. Water parameters should be slightly acidic and have low carbonate hardness. Sometimes, to recreate the brownish water tint characteristic of their natural habitat, tannin extracts or leaves of trees high in tannins are used, such as Indian almond, oak, or European beech. Leaves are dried first, then soaked until they sink, and only then placed in the aquarium. Tannins gradually leach into the water as the leaves decompose, giving it the desired colour. Leaves should be replaced every few weeks. Tank maintenance includes regular cleaning of the substrate of organic debris and weekly partial water changes of 10–15% of the total volume.