This catfish leads a predominantly nocturnal lifestyle, so during the day, it actively seeks shelter. When setting up an aquarium for it, it is crucial to provide a sufficient number of places where it can hide. These can be dense plant thickets, various snags, or other natural and artificial decor elements. Another key element of the setup is a sandy substrate, in which the catfish will not only dig for food but also burrow, using it as a hiding place. Acanthobunocephalus nicoi is undemanding in its diet and is an omnivorous species. It readily accepts most sinking foods of appropriate size. It is recommended to feed the catfish shortly before the aquarium lighting is turned off. When cohabiting with other species, it will pick up leftover food from its tank mates. Optimal conditions for its keeping include acidic and soft water with a temperature not exceeding 25°C. Regular aquarium maintenance is critically important to prevent the accumulation of organic waste, which is especially significant for bottom dwellers. It is well compatible with many other fish species of comparable size that prefer to inhabit the water column or near its surface.