The calico swordtail, like other livebearing fish, is generally regarded as an undemanding aquarium inhabitant. This fish adapts readily to a wide range of temperatures and water chemistry parameters and has no special requirements for tank setup. It can even be kept in slightly brackish water. Care is often straightforward. For example, in a dedicated swordtail tank, a heater is sometimes unnecessary, and if the tank volume is large and the number of fish is low (1–2 individuals per 100 litres), a simple air-lift filter is sufficient. Regular maintenance includes a 15–20% water change weekly and removal of accumulated organic matter such as uneaten food and waste. Regarding feeding, the calico swordtail readily accepts a variety of suitably-sized foods. A varied diet that includes dry, frozen, and live foods is optimal. However, daily feeding can be based entirely on standard flakes or pellets. These fish coexist peacefully with their own kind and other non-aggressive freshwater species. Avoid aggressive or territorial neighbours. Swordtails can hybridize with related species such as platies and mollies, producing hybrid offspring, which may raise questions about keeping them together.