These catfish are easy to keep and do not have high demands, making them a good choice for both beginners and experienced aquarists. Corydoras simulatus shows adaptability to various living conditions, provided that basic requirements are met: the water must be clean and warm, with acceptable pH and dGH values, the substrate soft, and there must be several shelters where the catfish can find refuge. Aquarium maintenance for these fish does not present significant difficulties and is similar to keeping most other freshwater species. It is recommended to perform weekly water changes of 15–20% of the volume, regularly remove organic waste (uneaten food, metabolic products), clean decor elements and aquarium walls of plaque, and conduct a prophylactic inspection of equipment. As for feeding, being bottom dwellers, these catfish prefer food that sinks and is accessible at the bottom. This is, perhaps, the only condition regarding their diet. They readily accept most common foods, whether dry granules, gel-based, frozen, or live options. In terms of behavior and compatibility, Corydoras simulatus is among the most peaceful aquarium inhabitants. They coexist perfectly with their own kind and with other fish species. Almost any fish that will not consider Cory catfish as a food source will be suitable as tank mates.