Lake Sentani rainbowfish are susceptible to diseases typical of the Melanotaeniidae family, which arise when keeping conditions are violated. The fish are sensitive to water quality, so the accumulation of organic waste and high levels of ammonia or nitrites quickly provoke bacterial infections, manifesting as fin erosion, ulcers, or cloudy mucous membranes. Also, under stress caused by sharp fluctuations in parameters or overcrowding, the species is prone to ichthyophthiriasis (white spots on the body) and fungal infections. Disease prevention involves maintaining stable water parameters and regular water changes. A particular danger is the species' tendency to hybridize with other members of the genus, which, in uncontrolled breeding, weakens the immunity of the offspring and leads to population degeneration. To maintain fish health, it is recommended to avoid keeping them in the same aquarium with closely related species, as this not only leads to a loss of line purity but also complicates the diagnosis of species-specific conditions due to the external similarity of individuals.