This is a very mobile and active fish that requires sufficient swimming space. For keeping a single specimen of Pseudanos trimaculatus, an aquarium of 80 L or more will be needed. However, for a group of 6–8 individuals, an aquarium of significantly larger size – 350–400 L or more – will be required. When decorating the aquarium, it is important to provide hiding places: these can be dense thickets of plants, snags, as well as various artificial or natural decorations. At the same time, sufficient open water space for swimming must be left. Given the predominantly herbivorous diet of these fish, when decorating the aquarium, preference should be given to fast-growing plant species with tough leaves. Plants with soft and delicate leaves are likely to be damaged or completely eaten. Extensive natural habitats have allowed this species to successfully adapt to a wide range of hydrochemical parameters. For the aquarist, this greatly simplifies the water preparation process during aquarium maintenance. The main condition is to ensure the stability of pH and dGH parameters and to prevent excessive accumulation of organic waste. The main element of the daily diet should be plant-based foods, but with sufficient protein components. Blanched spinach, lettuce leaves, as well as pieces of cucumbers and zucchini will serve as an excellent addition to the diet. Although the Three-spot Anostomus can eat algae, it should not be considered an effective means of combating them.