The optimal aquarium volume for several Apistogramma nijsseni starts from 60 liters. When setting up the tank, it is preferable to use a sandy substrate, as well as a large number of shelters created from snags or other decorative elements. It is also important to provide thickets of shade-loving plants and clusters of floating vegetation on the surface. Lighting should be subdued. The water composition requires slightly acidic pH values and low carbonate hardness. To recreate the characteristic brownish tint of the water, reminiscent of their natural environment, beech, oak, Indian almond leaves, or special essences are often added. The leaves must first be dried, soaked, and then placed in the aquarium. As they decompose, the water will be enriched with tannins and acquire a tea-like color. To maintain high water quality, a powerful filtration system with effective biological purification will need to be installed. Since filters are the main source of internal current, they should be positioned to minimize water movement, as otherwise, the fish may experience discomfort.