For a single pair of fish, an aquarium of 55 liters or more is considered optimal. When setting up the tank, it is important to provide areas with dense vegetation and plenty of hiding places, which can be snags, caves, grottoes, or even ceramic pots lying on their side. Nanochromis transvestitus shows a tendency to dig in the substrate, so it is advisable to use sand or a similar substrate. It is important to note that this type of substrate, if improperly chosen or if the filtration system is incorrectly installed, can clog it. Optimal water conditions are characterized by slightly acidic pH and soft dGH. To recreate a natural aquatic environment similar to their wild habitat, special essences with tannins can be used, or European oak, beech, or Indian almond leaves. An alternative method is to use alder cone filter media. Aquarium care includes regular cleaning of the substrate from organic waste and weekly partial water changes (15–20% of the total volume).